Plasmalogens Can Cure a Rare Genetic Brain DiseaseOctober 31, 2022
Plasmalogens Can Cure A Genetic Brain Disease
Ok, so RCDP is rare. Very rare. Only 2-3 children a year in all of North America and Europe. It is a genetic defect in the critical proteins that make plasmalogen precursors in your peroxisomes called RCDP2 and RCDP1,3. The resulting disease, RCDP or Rhizomelic Chondrodysplasia Punctata, has several forms. The severe form shows terrible problems within months of birth with the affected children dying by age 12. The milder form still has mental retardation and requires lifetime care. Terrible diseases. Why are they important for us to know about?
RCDP is essentially a mirror image of Alzheimer's, much accelerated. That's why.
Here is some core biology. A baby's brain is filled with wires, called axons, between cells up until about 20 weeks. Those fetal brain cells can't talk to each other until those connecting axons get insulated by oligodendrocytes. The insulation material are plasmalogens. The links, called synapses, are also 70% plasmalogen. Starting at week 20, a fetus needs huge amounts of plasmalogen fats. Mom gets a big drain on her supply of plasmalogens to provide that hungry fetus's brain. At birth, a newborn is severely plasmalogen deficient just because of the demand of the rapidly growing brain. Guess what the best source of plasmalogen lipids are? You are right! Mom's breast milk. Breast milk from humans has 10 times the plasmalogen content of cow milk. Formula has none. A baby's brain is growing at a tremendous rate for the first 6 months-2 years, which is why breastfeeding is so beneficial for infants.
That's when RCDP kicks in. Without a plasmalogen source, the baby's brain can't keep developing after birth, and even more, after weaning, RCDP infants start showing symptoms. Without plasmalogens to supply the building blocks to their neurons and axons (cells and wires in between), the affected infants descend into endless seizures and disability.
Why is this a mirror image of Alzheimer's? We now know that you can simplify Alzheimer's to the loss of plasmalogens over years resulting in the loss of synapses or links between brain cells. Our working memory is embedded in the complex web of synapses laid down over time. The human brain actually keeps accumulating total mass and volume of plasmalogen fats and synapses up until age 50. Yes, a 50-year-old brain is just about the most developed. From age 50 to 70, the average person will have lost 20% of their brain plasmalogen density. The human brain has so much redundancy and resilience that it can cover up that decline and hide it with "work-arounds". This column referenced a Yale study from this year in which cognitive function perfectly mirrors synapse density and plasmalogen density. RCDP occurs as the brain is growing and expanding and runs out of supply. Alzheimer's occurs as the brain is shrinking from the gradual loss of supply. As your plasmalogen supply declines, your synapses decline and you working memory declines.
Guess what happened just this last month to the first child suffering from RCDP treated with Prodrome GLIA! It took some 30 days before much change was seen but here is an entry from his mother's dairy on day 34. "His drooling has improved so much and he is chewing on his shirt way less (it has been a sensory thing for him). We used to need to change his shirt a couple of times per day because it was so wet. We don't change it at all anymore.". Next entry. "I will never in my life forget tonight. The joy they all felt playing together for the FIRST TIME ever. T understood cognitively how to interact and how to PLAY with his siblings".
This is the first case of RCDP that has been treated and has shown immediate repair. The genetic error of RCDP is so rare, there aren't a lot of kids to work on. But this illness is catching a brain disease right at the most vulnerable point of plasmalogen need. Alzheimer's comes much later after a mature development has occurred. Supplying the building blocks to rebuild the missing 20% of your plasmalogen supply, gives your brain the tools to start rebuilding redundancy and resilience and get back to learning and remembering.
www.What will Work for me. I'm all in. There is now increasing evidence that we can fix one disease of plasmalogen deficiency. And we now are getting more sophisticated at measuring our plasmalogen "ecosystem" with Goodenowe's test. The price of Prodrome Glia just dropped by 50% this month. Hopefully Prodrome Neuro can be produced more cheaply soon - that is supposedly the plan. A plan is in the works to start a study with autistic kids. There is some hint that may be helpful too. Wow!
References: Am J Med Gen , Neurology,
1. You can measure an infant's brain for synapse density. T or F. Answer: True
2. What is the disease RCDP? Answer: We don't expect you to remember what the acronym stands for. Just that it is an inborn error of metabolism that can't make plasmalogens. Very, very, rare.
3. When is an infant's need for plasmalogens the greatest? Answer: Right at birth, when the brain is growing the fastest.
4. What are the plasmalogens used for? Answer: They are the building blocks to make the insulation wiring of the brains and the synapses.
5. Oral replacement of plasmalogens in the first case has now demonstrated what? Answer: Within a month a dramatic reduction of repetitive, dysfunctional behavior and the reinitiation of play and social interaction.