How Low Plasmalogens Cause CancerApril 11, 2021
How Low Plasmalogens Start Cancer
Did you get that? We have a screening test in Plasmalogens around cancer that is emerging. Why didn't we know this earlier? Explain all this? Well, here goes. For starters, it is well known that many cancers have dramatically different rates between countries, and more importantly, over time. You can compare countries to each other and see huge variability. For example, data from the Global Cancer Observatory will show you that America has 15 times the rate of thyroid cancer in India. There must be something in the environment. Ok, let's follow that thread.
We have also known for some 40 years that there is a curious connection in cholesterol synthesis, export, and blood lipids in cancers. In fact, lipid synthesis disorders are far more consistent in cancers than blood glucose disorders. When you give cancer-causing chemicals to experimental animals, the first thing that happens is dysregulation of lipids, with abnormal LDLs and changes in LDLs and HDLs way before the cancer shows up, with those changes being predictive of cancer coming down the pike. Hence, the possibility of a screening test. Again, as an example, breast cancer is strongly associated with very high HDLs and lower LDLs. (Sort of the opposite of what you are used to thinking of protection from heart disease). To prevent breast cancer, you want HIGHER, yes HIGHER LDLs, and lower HDLs. Wrap your brain around that one. (We will get to the explanation: hang in there.). You see the exact same pattern in Chinese men with lung cancer. Danger from high HDLs and low LDLs. I mean a 347% increased risk with that pattern. That's huge. What's amiss?
If you don't mind my geeking out a little bit: here it is. Tiny changes in the content of cholesterol in your membranes results in massive changes in glucose transport into a cell. We've known that for 40 years, and it got lost in the pile of other research. All cancers must make that change. They need glucose, hence, they also must, must, must alter their membranes to put more cholesterol molecules into their cell walls. The mitochondria of cancer cells have three times the cholesterol in them compared to normal cells. That makes the membranes much more rigid, and much more open to importing the glucose that cancer cells thrive on. It also makes the membranes much more prone to exporting citrate, the baseline fuel that cancers get most of their energy from. Energy in cancer cells, instead of going into making ATP gets diverted into making more cholesterol and exported in HDL particles. (See how cancer cells got to high HDLs?). The normal feedback look inside normal mitochondria is lost, and that feedback loop is dependent upon the membrane content of plasmalogens and cholesterol. Cholesterol goes up, plasmalogens go down. There you have it. Low plasmalogens are staring us in the face.
Cancer cells get only 20% of their energy from glucose. Where do they get the rest of their energy from? If you want to do a deeper dive, you can go down that rabbit hole and find that cancer cells have to get glutamine as an energy source and from which they make aspartate and polyamines. Blah, blah, blah. I love and now understand it, but it is complicated. The nexus it turns on is the plasmalogen levels in your membranes.
Pull back out and take the bigger view. Follow the dominoes as they drop. The plasmalogens in your membranes are the key feature here. Cancer cells can't get more cholesterol into their membranes until you lose control of cholesterol manufacturing and exporting. That takes lower plasmalogens. Once you have that, you can start bulking up the cholesterol in your mitochondrial membranes and in your blood with high HDLs. That allows you to change your mitochondria to making more citrate and lactate, and off you go. More extramitochondrial acetyl CoA and citrate in your cells, the faster the cancer grows. Want to slow a cancer down? Well, in bench research, we can do it by replacing plasmalogens. More plasmalogens in your membranes, better cholesterol control.....better cancer control. The tip of the spear is low plasmalogens.
www.What will Work for me. That data shows that virtually every cancer has low plasmalogens for years prior to the cancer showing up. We aren't quite sure why plasmalogen content of your membranes drops. But there it is. Low plasmalogens in your blood are like a prepared garden for cancer to thrive in. Do we have proof that you can hold cancer off by taking plasmalogens? Not yet. We sure have bench research showing it slows them down. Now, can we measure them in you? YES! Can we replace them? YES. Are they dangerous to take? NO! NO! NO! It's just food. It's just fish oil placed in just the right places with just the right chemical bonds. At the heart of it, plasmalogens play a huge role in making every membrane in your body work properly. And if you look at folks with normal plasmalogens in their blood, they simply don't ever get cancer, dementia, or just plain die. They are the few chosen who get to live to 100 with a working brain. I want to be on that team. I measured mine. I was in the moderately low group. My garden was all rototilled and ready for cancer to grow. For Alzheimer's to blossom. You know how long it takes to get your blood level to normal? One dose. I'm putting my nickel down on that bet: normal plasmalogens dictate a long and healthy life.
References: Global Cancer Observatory, Critical Reviews in Biochemistry, Jr Natl Cancer Instit, Int Jr of Cancer, Brain Sci, Biochemistry, Science Direct,Euro Jr Biochem, Science Direct, Membrane Anomalies of Tumor Cells, Lipids in Health and Disease, Plos One, Lipids in Health and Disease,
1. What are plasmalogens? Answer: They are the lipids that have very unique characteristics of being able to capture free radicals (making them the neutralizer of first choice in your body). They are also uniquely extremely liquid which makes membranes with embedded proteins work better, thereby allowing regulatory functions, like the control of cholesterol to work better.
2. What happens if I have low plasmalogens? Answer. You won't know it. You don't feel anything. But your cells begin to struggle. You have a fertile field in which trouble can happen. Bit by bit, your neurons give up and collapse. Your links in your brain start declining. On and on. Here you heard about cancer. We haven't gotten to all-cause mortality yet. (Debbie Downer has her way with you.)
3. Why didn't we know this sooner? Answer: This has been a whole new field of science developing by starting from the opposite end of research. Instead of studying a disease, Dayan Goodenowe developed and discovered the process of examining every measurable compound in your body that was in trouble over time as people got sick. That required supercomputing power and long-term epidemiological research.
4. Is it dangerous to take plasmalogens as supplements? Answer. No, they are just food. It's just the right food. You can't take oral plasmalogens as they get digested in your stomach. Goodenowe has been a unique genius in developing and patenting the chemical process of manufacturing plasmalogen precursors that survive your gut.
5. Where can I get tested? Answer: You can get it directly from Prodrome.com or any doctor affiliated with Dr. Goodenowe's lab. We do it at Brookfield Longevity and give you a price break because our volume allows discounts.