Peptide Primer II BPC 157 Body Protective Compound

May 13, 2019

ReferencesJ Orthopedic ResearchExamineInflammopharmacologyJ Physiol Paris,Life SciMIT NewsCurr Med Chem,


Body Protective Compound is a modestly large protein discovered in mammalian gastric juice. It has a molecular weight of 40,000 and is a huge molecule. After chopping off pieces of it into smaller fragments, a 15 amino acid sequence was isolated that has the beneficial effects that folks desire to use for clinical benefits. There you have it! The ability to manufacture peptides has exploded recently, and naturally, the smaller the better. It's relatively easy now to plug the formula in for a 15 amino acid sequence and then manufacture pure, compounded peptide results.

What does BPC-157 do? It heals tendons. Tendons and connective tissue are sort of silent little partners that hold us together. As we get older, we heal more slowly. When we exercise and are out of shape, we injure ourselves. When we try to build houses at age 60 and have never done it before, we strain our shoulders, hurt our backs. When we start Cross-Fit after spending a day sitting at a desk, we injure the tendons in our necks and elbows....and where-ever. 
How about when we have surgery? The surgeon cuts through connective tissue and stitches together torn rotator cuffs, twisted knee menisci, strained carpal tunnels..you name it. 

What about GI effects? BPC-157 is stable in gastric juice for a full day. That's where the big protein was found. It leads to healing esophagitis and all sorts of inflammatory bowel conditions....in animal models. Hmmm....do we have any human studies yet? Precious few. 
Want to get better faster? Then you want a compound that is the natural messenger your body used to have that instructs it to heal itself. You want the peptide your cells are used to seeing that instruct them to do their job and get back in shape. What is BPC-157 doing? Just that. It accelerates the spreading out of tendon fibroblasts by 230% with its effect starting in minutes. It increases survival of new fibroblasts under oxidative stress - that's code for saying it makes the repair tissue live longer, spread faster, and put stuff together again more effectively. If you want a really deep dive into its physiology read Chang's nice review from Physiology.org. 
What's the big picture? To reiterate; as we age we lose the ability to generate hormones, peptides, messengers, exosomes, whatever you want to call it. We don't make them anymore as we get older. Living longer, better, requires us to be savvy and learn the means by which we can counter the inevitable decline in our ability to heal and repair ourselves from injury. That we live to age 60 is a miracle enough as it is, without the risks we take on of riding bicycles, climbing ladders, lifting weights, painting houses. When we get injured, we need casts and surgery, physical therapists and hospitals, ERs and ambulances.......and the messengers with which we heal ourselves.

Want to get better after surgery, faster? Want to fix that nagging shoulder pain after rotater cuff surgery? Want your tennis elbow to fix? Want to get off GERD medications. Want to cool off your inflammatory bowel disease?


WWW: What will work for me. I'm all in. There has been no known documented toxic side effect of BPC-157. It is made up of amino acids, after all. That's what we are made up. Hard to be allergic. And when compounded by a compounding pharmacy, that's the means by which we can legally get a peptide for which we may have profound benefit. I'm taking it right now for my aching neck that awakens me many nights. One week in, I can feel an effect. My foot still aches from falling off the ladder. I don't know if that will fix, but it's what is in my sights as an experiment on myself. Side effects? None with me.


Pop Quiz

  1. BPC-157 is what? Answer: A 15 amino acid peptide that is a fragment of a much, much larger protein called Body Protective Compound isolated from gastric juice.
  2. The fragment, BPC-157 does what to inflammed stomachs? Answer: Chill baby, chill. It appears to calm down animal models of GI inflammation dramatically.
  3. How does BPC-157 work? Answer: It turns on the activity of fibroblasts, the healing and growing cells of tendons and connective tissue, and angiogenesis, new blood vessels.
  4. Does BPC-157 have any side effects? Answer: Nope. Not found yet.
  5. Is it legal to get it? Answer: That's what a compounding pharmacy does. They make "medications", in this case peptides, to order from component parts. It's the ability to manufacture proteins with peptide connecting machines that allows this revolution to get into gear.
  6. What's the standard model of medical advancement? Answer: The randomized placebo controlled trial. Paid for with $ 100,000,000 dollars of pharma money. Not going to happen for a compound that Big Pharma can't patent.

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