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BioToxin VII: The Gluten Connection
November 06, 2017
References: Nature, Immunity, Clinical and Devel Immun, Surviving Mold,
How many folks do you know who are gluten sensitive? You hear some people scoff at the idea but you also know quite a few folks that say they just feel better when they are off gluten. They don't have celiac disease, at last most don't. So, what's up? Would you be surprised if you heard that biotoxins set off your innate immune response, and that sets up for the production of TH-17 immune cells, that tip you in the balance towards autoimmune disease? And gluten does that!
Step 4 in Shoemaker's Surviving Mold Pathway is to get off of gluten/amylose for at least 3 months if you have antibodies to Gluten. This is the next phase of the Shoemaker protocol: sequentially and progressively cleaning up all the sources of persistent inflammation. And actually, he calls for you being off amylose. Amylose is about 30% of most white carbs. It is composed of long strings of glucose hooked together at the 1,4 positions on the glucose molecule, making for a long, linear chain. Amylopectin is the other component of most starches. It is branched and less dense in formation. Plants can store more energy as amylose. Curiously, it's structure also binds iodine avidly, making for a dark color indicating the presence of amylose with iodine.
This is where future research is going to have a rich source of discovery. We don't know all the details yet. What we do see is that lowered MSH (melanocyte stimulating hormone) and elevated TGF-beta 1 leads to unbalanced TH17 immune cells. These are the regulatory cells that march you down the path to autoimmune disease. And oddly enough, we see antibodies to gluten like IGg and IgA antibodies to gluten in biotoxin disease. That's what leads you to step 4.
Get off of anything that stimulates inflammation. It's not just wheat, it's all amylose products like potatoes and rice too. All white carbs.
Now, your brain, your gut and your immune system all make a team, a triad. When you have inflammation in your gut, your brain doesn't feel so good either. Biotoxins are setting off cytokines all over your body that are then blocking the leptin receptor in your brain, lowering your MSH. Without MSH to direct your immune system, your gut gets dysfunctional. Autoimmunity emerges. Gluten wasn't the first step, mold biotoxin set the table.
You thought your gluten sensitivity was set off by the changes made to wheat back in the 1950s when we tripled it's chromosomes. I thought that. May not be the sole problem The underlying dynamic may be that your innate immune system is goofy because of biotoxins from molds. And you are in the 25-30% of folks sensitive to those biotoxins. If you live and work in clean environments, you might not ever feel the effects. You can eat bread and potatoes all day long. But add in biotoxins and your genetic susceptibility takes over.
We have tantalizing clues that this is what's happening. Rock solid proof awaits. We do know that Hashimoto's gets better with wheat avoidance. We do know that Crohns and Sjogren's appear to be sensitive. Stay tuned.
WWW.What will work for me. I don't eat much wheat anymore. We just don't buy bread or potatoes. It becomes a lifestyle thing. Shoemaker asks the same as Functional medicine with wheat, 3 months without any. Now, that's hard. For those who are sensitive, the rewards are there. I can't wait for more science to figure out this connection more fully.
Gluten irritates your gut and sets off autoimmune disease? T or F Answer: We used to say this was true. We now think that biotoxins lower your MSH that then makes your immune system unable to protect your gut. That's the nuance.
To have an effective challenge of being gluten free, you need to be off for how long? Answer: Three months
If I put a drop of iodine into a cup of hot water with rice flour in it, it will instantly turn black, making for a great magic trick? T or F Answer: True. Amylose binds iodine avidly. It’s kind of fun. You can complete the trick with a tablespoon of green tea after your iodine turns the water black - if you want to really have fun with food chemistry tricks. Poof, clear again. Try it.
Turning off amylose sensitivity is the first step in fixing the inflamed body, once biotoxin is removed from your body and your MARCoNs are cleaned up. T or F Answer: That's it. Now we embark on tackling all the sources of inflammation and calming your hot body down.
Biotoxin illness spreads its trouble much further afield than I ever imagined. T or F Answer: Just wait till we get to hormones! True, true, true.