Biotoxin V: How do I Get Rid of Biotoxins?October 23, 2017
References: Biotoxin Journey
You now know that biotoxins circulate endlessly in folks whose immune system can't "see" the toxin and label it. You know that merry-go-round involves the toxin entering through your nose lungs most of the time, or ingested, or stung, or absorbed. From there the toxin sets off all sorts of cytokines in toll-receptor proteins all over your body. These cytokines descend on your primitive lizard brain, your hypothalamus, and essentially damage the leptin receptor that is the entry point to proper functioning of your POMC (pro-opiomelanocortin) system, that is foundational to your pituitary and most of your hormones.
The net effect of this blockade of the leptin system and POMC system are that you reduce the output of MSH, melanocyte stimulating hormone, which might be considered the "mother of all hormones" as it is so upstream from much of your endocrine system. You have trouble concentrating and remembering. You have a head ache. Your muscles ache. All your symptoms are nonspecific. All your traditional lab tests are normal. Now, the toxins circulate through your body and eventually find their way to your liver, which politely and promptly dumps them into your bile. From your bile the toxin ends up in your gut. In your gut, it passes down to your colon, where, without an antibody label on it (because your immune system can't see it) you reabsorb it.
The Merry-Go-Round. The toxin circulates endlessly. And that is the key! That is also how we can rid you of it. Cholestyramine (CSM) is an old-fashioned cholesterol drug, invented to soak up bile acids in your gut, which was supposed to lower cholesterol as a secondary effect. Turns out that strategy to reduce blood cholesterol was an ineffective remedy for cholesterol, but brilliant for CIRS. It is a potent binding agent nevertheless. It binds almost every biotoxin while it is in your gut. The shapes of biotoxins make them quite fat soluble, so they pass through membranes easily so binding them is the only way off the merry-go-round. A second drug called colesevelam (Welchol) also works, but takes 2-3 times the time to do it. It's a good backup for folks who get too constipated with CSM. The dose of cholestyramine is 4 grams, four times a day. You have to take it before the meal with water so that it has time to expand and fluff up to absorb the biotoxin that gets excreted in your bile. The standard teaching is 30 minutes ahead of time but no-one can remember that. Make 15 minutes a plan. But anytime is better than missing a dose.
Now, you may get worse. Some folks do. We aren't sure why but the solution is to drop way back and start at much lower doses and gradually increase slowly. Start with 1/4 tsp twice a day and increase by 1/4 tsp every other day spread out over your four doses. Take a full month to get to a full dose.
That is typically one scoop of the standard preparations and the dose recommended by the FDA for cholesterol care. There are some caveats. Folks who have Lyme will tend to have a flare of symptoms shortly after starting CSM (Herxheimer reaction). Collecting data like C3a and C4a and MMP9 before hand and with a flare will confirm the real perpetrator, and allow countermeasures ahead of time like pretreatment with a no-amylose diet, fish oil or pioglitizone which blocks PPAR receptors and reduces TNF-alpha production). And in a month you are better. Did you get that? It seems impossibly complex when you read the above, but the cure is easy.
One month, binding agent, fixed! That is totally, unbelievable, factually true (20-40% of the time). But you have to watch the details. Can you get better if you are still living in a contaminated home? No. Can you get better if you have Merry-Go-Round #2 in your nose going on? No. Can you get better if your whole pituitary POMC system is screwed up? No. But those are all reduced likelihood events, and the subjects of coming weeks detail. Keep reading.
Notice, I didn't mention any of ten other binding agents. You know why? Because Shoemaker has checked all of them against placebo controls and found none of them (charcoal, clay, zeolite,) to work like cholestyramine. So, don't bother.
WWW.What will work for me. This is a whole new field of medicine. The cure seems very simple but it has so many caveats that the devil is in the details. Cholestyramine is a magically simple drug, provided you have all your ducks lined up. In the meantime, I'm looking into ways to clean up basements and circulate air. My neighbor has had his basement being vented with an aerator that pushes out air and dries out basements better than dehumidifiers. I'm exploring one for myself.
- The best way to excrete biotoxins is to snag them in your gut? T or F Answer: True. You got it. You read the book. Nice work
- The best drug to do this is.........? Answer: Cholestyramine
- The right dose is..............? Answer: One scoop or 9 grams
- Many binding agents bind mold toxins? T or F Answer: Well, only one other works (Welchol) and it works at 1/2 to 1/3 the pace.
- Taking cholestyramine, one time a day will keep me protected? Answer: Nope. Seems to be a threshold of dose to work. 4 grams a day might be the lease you can take to be effective, and at least it keeps your constipation at bay. Ok, we didn't mention it above but it is in the references.